Parabens are methyl paraben, ethyl paraben, propyl paraben are added to bread, butter, cakes, pastries and other confectionery products
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|Parabens are characterized by low toxicity, efficacy over a broad pH range, does not have a specific odor, do not alter the organoleptic properties of the product color and taste, which are introduced|
Parabens are not the invention of scientists are natural substances that are found in various plants. Benzoic acid rich lingonberries and cranberries. In phytotherapy these berries used in renal diseases as antimicrobial agents.
Willow bark contains hydroxybenzoic (salicylic acid), which herbalists used to treat wounds and burns - in the form of powder or decoction. Methylparaben, acting as an antimicrobial agent found in blueberries. It's all natural parabens.
A synthetic? As a rule, the parabens are used in products with a high content of aqueous phase. Methyl paraben, ethyl paraben, propyl paraben are added to bread, butter, cakes, pastries and other confectionery products. Their coded names can be found on the labels of canned fish, mayonnaise, sauces, ketchup. Preservatives prolong shelf life and marketing of products that have deteriorated after a couple of days, if not contain parabens.
Shampoos, moisturizers, hair conditioners, shaving gels, lubricants (grease), sprays, toothpastes, soaps, deodorants, creams and masks for the skin, cleansing lotions and tonics, cosmetics - this is not a complete list of the cosmetic products, that contain parabens in its composition. Virtually any cream or serum without preservatives very quickly turn into a flaked product unfit for use. Therefore, the complete absence of preservatives in the medicinal and decorative cosmetics is impossible.
The concentration of the parabens is not uniform and depends on the shelf life of a cosmetic product. Than it is, the higher the concentration of parabens. And second, what it depends on their concentration, - the very form of the means of manufacture.
For example, in aerosol deodorants balloon's rarely contain parabens as hermetically closed and do not need preservatives. Deodorants in the form of dry sticks contain most of parabens because more active than others in contact with the air. The same can be said about deokremah that are squeezed from a tube. Roll-on deodorant occupy an intermediate position on the content of parabens - between the aerosol packaging and dry sticks.
Finally, the pharmaceutical industry. Soft dosage forms (ointments, creams, gels, liniments, rectal and vaginal suppositories), liquid dosage forms (syrups, suspensions, tinctures, decoctions, nasal drops, eye and ear), various parenteral injectable forms, gelatin marketing capsules and even dressings - all contain preservatives, and in most cases it is parabens. It concerns and pharmaceuticals and dietary supplements. In the drugstore reality parabens are used for a long time. When there were no pharmaceutical companies and any medication was manufactured in the pharmacy, the shelf life is often limited to a few days, and the pharmacist had to do medicine again and again, and the patient - regularly come to the pharmacy for a refill of the drug. Remember, any cooked decoction or infusion of their own can not be stored for more than three days, even in the refrigerator. This is true not only of liquid dosage forms, but also soft ointment without preservative "will not survive" and the week. Currently, medicines may have a shelf life of up to several years. That's what parabens! Because the use of parabens (preservatives or other) in cosmetics, medicines and food products necessary, as these products have a property to deteriorate.
Efficacy parabens as preservatives due to their bactericidal and fungicidal properties. These compounds have a broad spectrum of action. They disrupt the permeability of the cytoplasmic membrane of a microorganism or fungus cells, resulting in changes of the membrane transport function necessary for the life of the substance (glucose and proline) does not fall within cells and harmful metabolic products are not displayed, which leads to the death of the microorganism. In addition, parabens inhibit mitochondrial function, which also affects the activity of microorganisms.
The spectrum of action of each paraben has its own characteristics. For example, methylparaben better inhibits the growth of molds, and propyl paraben - yeast. Furthermore, parabens have weak estrogenic activity which is much weaker than the activity of various phytoestrogens contained in the products.
Parabens are characterized by low toxicity, efficacy over a broad pH range, does not have a specific odor, color and taste, do not alter the organoleptic properties of the product, which must be entered. They are not mutagenic. Due to the presence in their molecules parabens hydroxyl group can react with proteins, lecithin, cellulose esters, iron ions et al., As well as actively adsorbed polyethylene packaging that must be considered when selecting the latter.
When the parabens contained in foods fall into the gastrointestinal tract, they are quickly absorbed, metabolized and excreted from the body, does not accumulate in it. As a result of metabolism parabens formed well known substance whose safety for man has long proved: p-hydroxybenzoic acid, p-hydroxybenzoic glucuronide, p-karboksifenilsulfat. These metabolites no estrogenic activity, unlike primary products.
When applied to the skin parabens quickly pass through the epidermal barrier; with prolonged use they can accumulate in the epidermis and dermis. But already in the first 24 hours in the skin breaks down 30% methylparaben and other parabens are destroyed more slowly.
DOSAGE AND CONCENTRATION
In food products parabens content ranges from 0.04 to 0.1%. Their radio concentra calculated per kilogram of body weight - so that the content paraben was less than 10 mg per 1 kg of food consumption calculation rules.
For cosmetic and pharmaceuticals have a maximum dosage of paraben (0.4%) and a mixture of parabens in one product (0.8%). The medications most commonly used synergistic mixture of methyl and propyl paraben in a ratio of from 2: 1 to 4: 1.
This is not a complete list of drugs that contain parabens, if produced in a certain form, which requires the presence of preservatives. Ointments "Akriderm", "Apilak", "Acyclovir", "Hydrocortisone", "gioksizon", "diclofenac", "Mikozolon", "Oksizon", "prednisolone", "Triakord", "ftorokort", "Chondroxide"; creams "Akriderm", "Candide B", "Litikord", "pimafukort", "Skinkap"; gels "Lidocaine," "Luan gel", "Solkoseril", "flutsinar"; liniments, "sinaflana"; syrups "Clearance", "Codelac"; slurry "Clotrimazole"; suppositories "Aproksid" "Nystatin" "Relief". Concentration in different dosage forms ranges from 0.01 to 0.08%.
At present, the representatives of the cosmetic and pharmaceutical industry and the European Committee for the protection of consumers believe that methyl paraben and ethyl paraben, like most other auxiliary ingredients are completely safe even with prolonged use.
Currently, in Europe, as w ell as the USA and Japan, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, izopropilparaben, benzylparaben and their sodium salts are permitted for use in pharmaceutical and cosmetic preparations and foods and considered safe to 0.8 % in the total concentration of up to 0.4% in individual concentrations (in cosmetic and pharmaceutical products).